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SUBOXONE sublingual tablet is an uncoated hexagonal orange tablet, debossed with an alphanumeric word identifying the product and strength. It contains buprenorphine HCl, a partial agonist at the mu-opioid receptor, and naloxone HCl dihydrate, an opioid receptor antagonist, at a ratio of 4:1 (ratio

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Because buprenorphine (the primary active ingredient of Suboxone® and Subutex®) is a partial mu-opioid agonist with a maximal effect less than that of a full mu-opioid agonist (eg, morphine, methadone, heroin), the induction regimen can be more aggressive.

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Dependent on heroin or short-acting opioids: initiate induction with either Suboxone film or buprenorphine monotherapy (SL tabs) at least 6hrs after last opioid dose.

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Approved for clinical use in October 2002 by the Food and Drug Administration (FDA), buprenorphine represents the latest advance in medication-assisted treatment (MAT). Medications such as buprenorphine, in combination with counseling and behavioral therapies, provide a whole-patient approach to the treatment of opioid dependency. When taken as prescribed, buprenorphine is safe and effective.

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SUBOXONE ® (buprenorphine and naloxone) Sublingual Film (CIII) is a prescription medicine indicated for treatment of opioid dependence and should be used as part of a complete treatment plan to include counseling and psychosocial support.

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NARCAN ® (naloxone HCl) Nasal Spray is used for the treatment of an opioid emergency or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

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Buprenorphine HCL/naloxone HCL can help such individuals through the usually difficult process of overcoming their dependencies. Sold under the brand name Suboxone, buprenorphine HCL/naloxone HCL comes as sublingual tablets or film that you place under your tongue.